CLINICOLABORATORY diagnostic CRITERIA FOR CHRONIC CYTOMEGALOVIRUS INFECTION IN EARLY AGE CHILDREN

Abstract

Aim. To determine the clinicolaboratory diagnostic criteria for chronic cytomegalovirus infection among children of early age, so as to optimize diagnosis in conditions of children’s polyclinic. Materials and methods. The object of the study included immunocompromised children with verified cytomegalovirus infection (CMVI) using the method of qualitative saliva and urinary PCR by means of the test-system produced by “Central Scientific Research Institute of Epidemiology”, “AmpliSens CMV-screen/monitor-FL” (Moscow) (61 patients, total sampling). Patients aged 3-6 months (13 %), 6-12 months (21 %), 1-3 years (43 %), 3-7 years (23 %) were sent from Perm polyclinics to receive consultations, clarify the diagnosis and correct the therapy. Results. According to statistical reports of Perm children’s polyclinics for 2013, frequency of CMVI diagnosis in the group of early age children who frequently fall ill (23,1 %) was stated that makes half of cases of the other intrauterine infections (44,7 %). The group of immunocompromised ambulatory patients (61 children aged 3 months to 7 years) with verified chronic CMVI was examined. Clinicolaboratory secondary immunodeficiency (SID) markers from birth or the first months of life were revealed. A marked dysbiotic status of oropharynx associated with Epstein-Barr infection and type 6 herpesviral infection was diagnosed in 54,1 % of cases. Conclusions. Immunopathological syndromes were presented as infectious (77 %), lymphoproliferative (54,1 %) and allergic (44,3 %).