Clinicohistological Correlation and Cost-effectiveness of routinely performed Histological Examination of Pregnancy Tissues obtained at Uterine Evacuation Procedure: Five-year Experience at a Secondary Care Hospital of Karachi, Pakistan

Abstract

ABSTRACT Aim To assess clinicohistological correlation and costeffectiveness of routinely performed histological examination of pregnancy tissue samples collected at surgical uterine evacuation Materials and methods In this retrospective study, medical record of patients admitted for incomplete miscarriage, missed miscarriage, and anembryonic miscarriage in the first trimester from January 2010 to August 2014 were reviewed. Histopathologic diagnosis of the tissue samples obtained via surgical uterine evacuation in these patients was compared with the preevacuation diagnosis. Results Specimens of 711 patients were sent after uterine evacuation. Histopathologic examination revealed normal product of conception in 681 patients (95.7%), while partial hydatidiform mole was diagnosed in 14 patients (1.9%). Complete hydatidiform mole was detected in only three cases (0.42%). Decidual tissue without chorionic villi was reported in 13 patients (1.8%). The diagnosis of complete mole was suspected in all three cases and in six cases of partial mole before procedure. Conclusion Findings of study did not show any diagnostic and financial benefit from routine histological examination of tissue removed at termination of pregnancy or emergency uterine evacuation. We recommend that histopathological examination be performed in cases where the diagnosis is uncertain, fewer tissues obtained during evacuation, when molar pregnancy is suspected, or when patients are considered at high risk for trophoblastic disease. How to cite this article Memon Z, Anjum N, Sheikh SS. Clinicohistological Correlation and Cost-effectiveness of routinely performed Histological Examination of Pregnancy Tissues obtained at Uterine Evacuation Procedure: Five-year Experience at a Secondary Care Hospital of Karachi, Pakistan. J South Asian Feder Obst Gynae 2017;9(1):1-4.