Clinicohaemato-biochemical changes in F0female Wistar rats fed with graded doses of citrinin

Abstract

The objective of the present study was to study the clinicohaemato-biochemical changes in F0 female Wistar rats on fed with graded doses of citrinin (CIT). The animals were divided into four groups comprising 25 males and 25 females each, that is, group I: 1ppm CIT; group II: 3ppm CIT; group III: 5ppm CIT; and group IV was kept as a control. The male and female animals of all the groups were kept separately and were fed basal rations containing the above mentioned concentrations of CIT for 10 weeks. After 10 weeks, male and female animals of respective groups were kept for mating. After successful mating, 10 pregnant females (F0 females) were allowed to give birth to young ones (F1 generation) naturally and were killed after the weaning period of 21 days. Clinical signs, body weight and various haemato-biochemical parameters were estimated in these F0 females. It was concluded that the dietary exposure of CIT in female rats 10 weeks prior to mating, during mating and during lactation was found to cause anaemia, leucocytopenia due to lymphocytopenia and hepato-renal toxicity as evidenced by certain biochemical parameters.