Abstract
BackgroundThe incidence of molar pregnancy has demonstrated marked geographic and ethnic differences. The reported data in Nepal is inconsistent with minimal published literature. Thus, we designed a study to determine prevalence of molar pregnancies and demonstrate clinical and epidemiological characteristics of the patients attending a tertiary care center in eastern Nepal.MethodsA retrospective review of medical records was conducted to determine the prevalence of molar pregnancies at the B.P. Koirala Institute of Health Sciences (BPKIHS) from the year 2008 to 2012. Secondary data from the medical records were analyzed. Annual and 5-year prevalence of molar pregnancy per 1000 live births was calculated. Demographic characteristics, clinical presentation, management methods and complications of molar pregnancy were studied.ResultsThe 5- year prevalence of molar pregnancy at BPKIHS is 4.17 per 1000 live births with annual prevalence ranging 3.8–4.5 per 1000 live births. More than one third of the patients were in the age group of 20–35 years and majority of them were of Hindu religion. For more than one third (41.7 %) of the patients, it was their first pregnancy while about 10 % gave a positive past history of molar pregnancy. Abnormal uterine bleeding (86.3 %) was the most frequent complaint, suction evacuation was the most common method of treatment and more than half of the patients required prolonged care after initial management.ConclusionThere is a need for studies at country level which will give us a national figure on molar pregnancies. Thus, a standardized clinic-epidemiological profile of molar pregnancy in Nepal can be created.
Highlights
The incidence of molar pregnancy has demonstrated marked geographic and ethnic differences
If not all, gestational trophoblastic disease (GTD) are potentially curable with the retention of reproductive function, once the correct diagnosis is made and treatment is commenced early enough [1,2,3,4] GTD constitutes a spectrum of tumors and tumor-like conditions characterized by
A total of 204 cases of molar pregnancy were included in this study
Summary
The incidence of molar pregnancy has demonstrated marked geographic and ethnic differences. If not all, GTDs are potentially curable with the retention of reproductive function, once the correct diagnosis is made and treatment is commenced early enough [1,2,3,4] GTD constitutes a spectrum of tumors and tumor-like conditions characterized by They include complete and partial hydatidiform mole, invasive mole, placental-site trophoblastic tumor (PSTT), and choriocarcinoma. In Nepal, hospitals in Kathmandu valley have recorded its incidence as 5.1, 2.9, 2.8, and 4.1 per 1000 live births [9]. These 10–20‐fold variations in the incidence of molar
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