Abstract
The aimof the review was to analyze published studies on the impact of opioid drug-drug interactions on the choice of analgesic therapy regimens.Material and methods.A systematic literature search was conducted using PubMed, Scopus, Web of Science, and E-library databases.Results.The review showed a clinical significance of pharmacokinetic interactions of opioids with other drugs in cancer pain treatment. The problems of individual choice of analgesics from different groups under conditions of co-morbidity and concomitant medication were discussed to ensure the effectiveness/safety of the treatment strategy affecting the quality of life of cancer patients.Conclusion.A comprehensive assessment of factors in patients receiving opioid analgesics is a predictor of effective and safe analgesic therapy.
Highlights
The review showed a clinical significance of pharmacokinetic interactions of opioids with other drugs in cancer pain treatment
The problems of individual choice of analgesics from different groups under conditions of co-morbidity and concomitant medication were discussed to ensure the effectiveness/safety of the treatment strategy affecting the quality of life of cancer patients
Цель исследования – анализ отечественной и зарубежной литературы о влиянии фармакокинетических лекарственных взаимодействий опиоидов на индивидуальный выбор эффективных и безопасных схем анальгетической терапии в онкологии
Summary
Цель исследования – анализ отечественной и зарубежной литературы о влиянии фармакокинетических лекарственных взаимодействий опиоидов на индивидуальный выбор эффективных и безопасных схем анальгетической терапии в онкологии. Материал и методы Проведен поиск русско- и англоязычных статей в научных базах PubMed, Scopus, Web of Science, E-library по ключевым словам: опиоиды, лекарственные взаимодействия, фармакокинетика, хронический болевой синдром, онкология, персонализация, обзор литературы, opioids, druginteractions, pharmacokinetics, chronic pain syndrome, oncology, personalization, literature review. Полифункциональный характер изоферментов CYP2D6 и CYP3А4, обеспечивающих 75 % метаболических превращений опиоидов, а также других ЛС и пищевых продуктов, предопределяет риск CYP-ассоциированных ЛВД в первую фазу лекарственного метаболизма [8].
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