Abstract
Pulmonary tumours with cilia formation are rare and are usually recognized as benign. Ciliated muconodular papillary tumour (CMPT) of lung is a rare entity recently described in 2002. It is characterized by the presence of papillary tumour consisting of ciliated columnar, goblet, and basal cells. Although most of its features are of a benign tumour, some histological characteristics do suggest low-grade malignancy. We describe a case of CPMT in a 36 year old male.
Highlights
Ciliated muconodular papillary tumour (CMPT) of lung is a rare entity recently described in 2002. It is characterized by the presence of papillary tumour consisting of ciliated columnar, goblet, and basal cells
After thorough investigations, Computerized Tomograohy (CT) scan of chest was advised which showed diffuse nodular infiltrations in right middle lobe. (Figure 1) A transbronchial biopsy of right lung was performed which showed the presence of papillary structure lined by benign ciliated respiratory epithelium with basal cells and mucous cells along with fragments of alveolar tissue. (Figure 2, 3) Immuno histochemistry shows positivity for cytokeratin (CK) 7, Carcinoembryonic antigen (CEA) and Thyroid transcription factor 1 (TTF-1)
CMPT of lung is a relatively new clinical entity described by Ishikawa in 2002, characterized by tubulopapillary, glandular or papillary architecture with tripartite morphology consisting of basal cells, mucinous cells, and ciliated cells involving the peripheral lung [1]
Summary
Ciliated muconodular papillary tumour (CMPT) of lung is a rare entity recently described in 2002. It is characterized by the presence of papillary tumour consisting of ciliated columnar, goblet, and basal cells. After thorough investigations, Computerized Tomograohy (CT) scan of chest was advised which showed diffuse nodular infiltrations in right middle lobe. (Figure 1) A transbronchial biopsy of right lung was performed which showed the presence of papillary structure lined by benign ciliated respiratory epithelium with basal cells and mucous cells along with fragments of alveolar tissue. Figure-1: Computerized Tomograohy (CT) scan of chest showed diffuse nodular infiltrations in right middle lobe. Figure-3: Papillary structure lined by benign ciliated respiratory epithelium with basal cells and mucous cells. Figure-3: Papillary structure lined by benign ciliated respiratory epithelium with basal cells and mucous cells. (H&E 40X)
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