Abstract
Mycotoxins in combinations may exert a greater negative health impact than the sum of their individual effects. A study was undertaken to investigate the clinico-pathological effect of feeding Fusarium sporotrichioides and T-2 toxin contaminated diet in broiler chicken Thirty six day old broiler chicks were randomly divided into two groups of 18 each. Treatment group was fed with diet containing Fusarium sporotrichioides culture with 4 mg T-2 toxin from 0 to 28 days and observed weekly for feed intake, body weight and various haematobiochemical parameters on 14th, 21st and 28th days of age. Control birds were fed with standard normal diet. Treatment group showed significant reduction in feed intake and body weight gain from 1st wk to 3rd wk, in addition to significant decrease in total erythrocyte count, hematocrit value and leukocyte count. There was significant increase in the serum levels of alkaline phosphatase, aspartate amino transferase, alanine amino transferase, blood urea nitrogen and creatinine, and insignificant decrease in the total protein and albumin concentration. Gross pathological changes included anemic carcasses, enlarged and pale yellowish tan friable liver and generalized atrophy of lymphoid organs. Microscopically, extensive degenerative changes were observed in hepatocytes and depletion of lymphocytes in different lymphoid tissues, which increased in severity with the duration of experiment.
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