Abstract
Gastric cancer has been one of the leading causes of cancer-related mortality over the past century. Today it is the 4th most common cancer in the world. Surgery remains the only major curative option. Majority of these cancers are found to be unresectable on laparotomy. Most gastric cancer patients are diagnosed with advanced disease with the development of distant metastases hence assessment of prognostic markers in these patients should be done. Hence based on above condition the present study was planned for Clinico Pathological Assessment of Gastric Cancer in Bihar Region.
 The present study was planned in Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India. The present study was planned from duration of June 2018 to December 2018. In the present study 50 cases of adenocarcinoma of stomach were enrolled and evaluated. The patients were diagnosed on clinical, radiological, endoscopic examination with confirmation by histopathological examination of either endoscopic biopsy or the resected specimen. The resected gastrectomy specimens were examined grossly and tumour location, tumour dimensions, extent of tumour invasion, metastasis to lymph nodes, number of lymph nodes involved, abnormality in surrounding mucosa were recorded.
 Gastric cancer is second most common cancer in male and fifth most common amongst females in East and Central Asia. The incidence of gastric cancer is twice as much in men as in women. Majority of cases had history of tobacco consumption, which clearly indicates the role of tobacco in causation of stomach cancer. Weak relation was seen in alcohol consumption. Screening of asymptomatic people in a high risk area may be useful in early detection of disease. Efforts to detect cancer early in developing countries would go a long way in reducing the disease burden and improving the outcome.
 Keywords: Gastric cancer, Mucinous adenocarcinoma, Tobacco, Metastasis, etc.
Highlights
Gastric cancer is the sixth most common cancer and the third most common cause of cancer-related death in the world. [1] rates are low in North America and Northern Europe—in the United States, stomach malignancy is currently the 15th most common cancer [2] —the disease remains difficult to cure in Western countries, primarily because most patients present with advanced disease.Gastric cancer was once the second most common cancer in the world
Majority of cases had history of tobacco consumption, which clearly indicates the role of tobacco in causation of stomach cancer
Results & Discussion: Gastric cancer is the 4th most commonly diagnosed cancer and the 2nd most common cause of cancer related deaths1 The overall 5 year survival rate of patients with resectable cancer is around 10-30 %. 2 Proximal stomach involvement is more common in western countries and is associated with more aggressive clinical course and a poorer prognosis
Summary
Gastric cancer is the sixth most common cancer and the third most common cause of cancer-related death in the world. [1] rates are low in North America and Northern Europe—in the United States, stomach malignancy is currently the 15th most common cancer [2] —the disease remains difficult to cure in Western countries, primarily because most patients present with advanced disease.Gastric cancer was once the second most common cancer in the world. [1] rates are low in North America and Northern Europe—in the United States, stomach malignancy is currently the 15th most common cancer [2] —the disease remains difficult to cure in Western countries, primarily because most patients present with advanced disease. Rates of stomach cancer have declined dramatically over the past half century. In the United States, stomach malignancy is currently the 15th most common cancer. Other factors likely contributing to the decline in stomach cancer rates include lower rates of chronic Helicobacter pylori infection, thanks to improved sanitation and use of antibiotics, and increased screening in some countries. Other factors likely contributing to the decline in stomach cancer rates include lower rates of chronic Helicobacter pylori infection, thanks to improved sanitation and use of antibiotics, and increased screening in some countries. [5]
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