Clinico Pathologic Features and Prognostic Grouping of Gastrointestinal Stromal Tumors (GISTS) in Peshawar: an Institutional Perspective

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Background: Gastrointestinal stromal tumours (GISTS) are uncommon gastrointestinal tumours. The prognosis is heavily influenced by the histopathologic features of resection specimens, which have not been investigated extensively in our community. Objective of the current study was to assess the histopathologic features of GISTs in our community, as well as how they affect their prognosis, based on what we found. Methodology: In this study, 60 cases of GISTs were included that were found and treated at Peshawar's Khyber Teaching Hospital from Jan, 2018 to December, 2020. Results: The patients' ages varied from 18 to 71 years. The stomach was the most common location for primary GISTs, accounting for 57.7% of cases.75% of the patients had spindle cell morphology, and 53.8 percent of them had a poor prognosis. It was shown that intestinal GISTs had a higher grade (70%) and were more likely to be in the elevated-risk prognosis groups than stomach gastrointestinal stromal tumor,(43 percent). However, there is no statistical difference found. Although GISTs are rare gastro-intestinal tumors, initial discovery and recognition of unfavorable histology properties are important for effective treatment. In stomach the GISTs is prevalent. However, intestinal gastrointestinal stromal tumors are shown to be more prevalent and more likely to be linked to poor prognostic factors. Moreover, further large-scale investigations are needed to confirm this conclusion. Keywords: Intestinal-GISTs, Stomach-GISTs, Peshawar, Gastrointestinal stromal tumors,