Abstract
The present study was aimed to assess the acute toxic effects of chlorpyrifos using rabbits as mammalian model. Chlorpyrifos @ 1000 mg kg−1 body weight as single oral dose (Lara-909 containing 50% chlorpyrifos) caused marked clinical changes with 50% mortality over 24 hr. Death was associated with muscular spasms and unconsciousness. Haematology showed a significant increase in mean lymphocyte and basophil counts. The blood glucose, total protein, albumin, globulin, alanine transaminase, aspartate aminotransferase, blood urea nitrogen and creatinine were not altered significantly. It was concluded that acute chlorpyrifos toxicity was characterized by marked clinical changes and mortality without any marked alterations in the haemato-biochemical indices.
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