Abstract
Over the past 50 years, advancements in pediatrics have transformed many infant and childhood disorders from lethal to treatable conditions.1-3 The medical and surgical interventions that enabled this progress have often, at the outset, generated considerable ambivalence and distress among clinical team members.4 Current advances in therapeutics face these persistent challenges.5,6 Given the acceleration in the development of novel targeted therapies, deepening our understanding of the general situation that gives rise to this distress—emotional as well as moral—and how to better address the distress is warranted.
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