Abstract
IntroductionMost anti-M antibodies are not active at 37°C and are thus of no clinical significance. Occasionally these antibodies have a wide thermal range and can lead to hemolytic transfusion reactions or hemolytic disease of the new born. Patient and methodsWe describe two cases of anti-M antibodies, both of which were clinically significant. ResultsThe first case was detected due to crossmatch incompatibility and the second presented as a blood group discrepancy. ConclusionWhen the antibody is active at 37°C, M antigen negative red cell units should be issued.
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