Abstract
Objective:To discuss application values of serum procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC) count in early diagnosis and treatment of neonatal bacterial infectious diseases.Methods:Clinical data of one hundred and thirty-six newborns with infectious diseases who were admitted into the hospital were retrospectively analyzed. They were divided into bacterial infection group (N=70) and non-bacterial infection group (N=66). Additionally, sixty-six healthy newborns who underwent physical examination in our hospital in the same period were selected as controls. Subjects in the three groups were all detected for serum PCT, CRP and WBC levels.Results:The levels of PCT, CRP and WBC in the bacterial infection group were much higher than those of the non-bacterial infection group and the healthy control group, and the differences had statistical significance (P<0.05). The positive rates of PCT, CRP and WBC of the bacterial infection group were higher than those of the non-bacterial infection group (P<0.05); the specificity and sensitivity of the PCT level were obviously higher than those of the CRP and WBC levels in diagnosing bacterial infectious diseases (P<0.05).Conclusion:Serum PCR, CRP and WBC levels are of high diagnostic values to neonatal infectious diseases. Compared to WBC and CRP, PCT is more sensitive index in the diagnosis of neonatal infectious diseases.
Highlights
Neonatal infectious diseases which are common in pediatric clinics refer to inflammatory diseases induced by pathogenic microorganism in neonatal period
Neonatal infectious diseases featured by sudden onset, rapid development and severe disease condition are of high risks to cause death.[1,2]
Neonatal period is a special period during the development of body; many infectious diseases are seen in this period, which may be because newborns have poor regulation ability and weak immune barrier and invasive operations such as invasive ventilators and deep vein catheterization are easy to induce nosocomial infection during emergency treatment of newborns.[3]
Summary
Neonatal infectious diseases which are common in pediatric clinics refer to inflammatory diseases induced by pathogenic microorganism in neonatal period. Different pathogenic infections can manifest similar clinical symptoms, which makes diagnosis difficult; the clarity of pathogenic bacteria is beneficial to early treatment and the improvement of curative effect.[4] Currently, there are many indexes for evaluating infectious diseases. The detection of white blood cell count is a major traditional approach for identifying bacterial infection; its sensitivity and specificity in diagnosing bacterial infection are low.[1] C-reactive protein (CRP), a kind of acute phase reactive protein synthesized by the liver under stress state, can regulate inflammatory reaction and defense infectious diseases.[5,6] A recent study demonstrated that, serum procalcitonin (PCT) level can help early identify bacterial and non-bacterial infection and could positively guide the clinical use of antibiotics.[7] This study investigated the application values of serum PCT, PCR and WBC in the early diagnosis of neonatal bacterial infectious diseases by analyzing their levels
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
