Clinical Value of Vascular Permeability Estimates Using Dynamic Susceptibility Contrast MRI: Improved Diagnostic Performance in Distinguishing Hypervascular Primary CNS Lymphoma from Glioblastoma.

B Lee,J.E Park,A Bjørnerud,J.H Kim,H.S Kim,J.Y Lee

doi:10.3174/ajnr.a5732

Abstract

A small subset of primary central nervous system lymphomas exhibits high cerebral blood volume, which is indistinguishable from that in glioblastoma on dynamic susceptibility contrast MR imaging. Our study aimed to test whether estimates of combined perfusion and vascular permeability metrics derived from DSC-MR imaging can improve the diagnostic performance in differentiating hypervascular primary central nervous system lymphoma from glioblastoma. A total of 119 patients (with 30 primary central nervous system lymphomas and 89 glioblastomas) exhibited hypervascular foci using the reference method of leakage-corrected CBV (reference-normalized CBV). An alternative postprocessing method used the tissue residue function to calculate vascular permeability (extraction fraction), leakage-corrected CBV, cerebral blood flow, and mean transit time. Parameters were compared using Mann-Whitney U tests, and the diagnostic performance to distinguish primary central nervous system lymphoma from glioblastoma was calculated using the area under the curve from the receiver operating characteristic curve and was cross-validated with bootstrapping. Hypervascular primary central nervous system lymphoma showed similar leakage-corrected normalized CBV and leakage-corrected CBV compared with glioblastoma (P > .05); however, primary central nervous system lymphoma exhibited a significantly higher extraction fraction (P < .001) and CBF (P = .01) and shorter MTT (P < .001) than glioblastoma. The extraction fraction showed the highest diagnostic performance (the area under the receiver operating characteristic curve [AUC], 0.78; 95% confidence interval, 0.69-0.85) for distinguishing hypervascular primary central nervous system lymphoma from glioblastoma, with a significantly higher performance than both CBV (AUC, 0.53-0.59, largest P = .02) and CBF (AUC, 0.72) and MTT (AUC, 0.71). Estimation of vascular permeability with DSC-MR imaging further characterizes hypervascular primary central nervous system lymphoma and improves diagnostic performance in glioblastoma differentiation.

Highlights

BACKGROUND AND PURPOSEA small subset of primary central nervous system lymphomas exhibits high cerebral blood volume, which is indistinguishable from that in glioblastoma on dynamic susceptibility contrast MR imaging
Hypervascular primary central nervous system lymphoma showed similar leakage-corrected normalized cerebral blood volume (CBV) and leakagecorrected CBV compared with glioblastoma (P Ͼ .05); primary central nervous system lymphoma exhibited a significantly higher extraction fraction (P Ͻ .001) and CBF (P ϭ .01) and shorter mean transit time (MTT) (P Ͻ .001) than glioblastoma
2 experienced neuroradiologists (J.Y.L. and J.E.P.), who did not participate in any other image review, independently determined the vascularity of primary central nervous system lymphoma (PCNSL) based on the CBV maps, as visualized in the PACS, which were processed using the reference method of Weisskoff et al[16] and Boxerman et al[10] as part of the routine workflow

Summary

Objectives

The purpose of our study was to test whether estimates of combined perfusion and permeability metrics obtained from DSC-MR imaging using the proposed method improve diagnostic performance in differentiating hypervascular PCNSL from glioblastoma

Methods

Results

Discussion

Conclusion