Abstract

背景与目的原发性肺癌是常见的恶性肿瘤之一,术前准确的局部淋巴结(N)分期可避免不必要的手术创伤,N3期已非手术治疗指征。本研究旨在探讨超声在诊断原发性肺癌锁骨上淋巴结转移及确定其分期中的应用价值。方法回顾性分析2012年10月-2013年11月经病理确诊为肺癌患者131例,所有患者均在术前行锁骨上区域的超声和增强计算机断层扫描(computed tomography, CT),对检查结果为阳性的患者行超声引导下穿刺活检,将组织病理学诊断作为淋巴结转移的诊断标准,对比两种检查方法与病理结果的一致性。结果131例肺癌患者中经病理证实共有50例为锁骨上淋巴结转移,经超声检查阳性者54例,转移者50例;增强CT检查阳性者41例,其中36例为恶性。超声的灵敏度、特异度、正确指数、阳性预测值及阴性预测值(分别为100%、95.06%、95.06%、92.59%、100%)明显高于增强CT(分别为72%、93.83%、65.83%、87.80%、84.44%)。两种方法在确定肺癌TNM分期准确性的差异存在统计学意义(P < 0.01)。结论与增强CT相比,超声在原发性肺癌锁骨上淋巴结转移方面具有较高的准确性、敏感性和特异性,并且能够更加准确地确定原发性肺癌的TNM分期。

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