Clinical value of serum β2-microglobulin combined with cystatin C and serum amyloid protein A in patients with type II diabetic nephropathy

Abstract

Objective To investigate serum β2 microglobulin(β2-MG), cystatin C(Cys C)and serum amyloid A(SAA)relationship with the typeⅡdiabetic nephropathy. Methods A retrospective study was performed on 250 cases of patients with type Ⅱ diabetic nephropathy who were admitted from June 2013 to December 2017.According to the result of urine trace albumin excretion rate test divided the patients into Ⅱ diabetes nephropathy group and the group with uncomplications of diabetes.Compared two groups of patients' serum β2-MG, Cys C and SAA levels, and analysis of three Ⅱ type, the relationship between clinical features of diabetic nephropathy in the receiver-operating characteristic curve(ROC)analysis three Ⅱ type of the diagnostic value of diabetic nephropathy, multivariate logistic regression analysis of the three type of Ⅱ diabetic nephropathy risk assessment of the value. Results Ⅱ diabetes nephropathy patients with serum β2-MG [(2.5 ±0.3)mg/L], Cys C [(7.1±1.4)mg/L] and SAA [(32.4±2.8)mg/L] levels were higher than in patients with uncomplicated diabetes group [(1.5±0.1)mg/L, (0.9±0.2)mg/L and(6.4±1.2)mg/L], and the difference was statistically significant(P<0.05); the three significantly related with Ⅱ diabetes kidney disease clinical stage, and the difference was statistically significant(P<0.05). ROC curve analysis showed that the combined β2- MG, serum Cys C and SAA distinguish Ⅱ diabetes nephropathy patients and no complications from diabetes area under curve(AUC)was 0.974(95% CI: 0.902 to 0.991, P<0.001), the sensitivity was 86.8%, 94.6%.Multiple logistic regression analysis showed that the β2-MG, serum Cys C and SAA levels is the pathogenesis of diabetic nephropathy Ⅱ type independent risk factors(P<0.05). Conclusion Serum β2-MG, serum Cys C and SAA can assist in the diagnosis of diabetic nephropathy Ⅱ type, at the same time, the three Ⅱ diabetes nephropathy risk assessment also has potential value. Key words: β2-microglobulin; Cystatin c; Serum amyloid protein A; Type 2 diabetic nephropathy