Clinical value of polyene phosphatidyl choline combined with lifestyle intervention in the treatment of non-alcoholic fatty liver

Abstract

Objective To investigate the clinical value of polyene phosphatidyl choline combined with lifestyle intervention in the treatment of non-alcoholic fatty liver.Methods A total of 120 cases of non-alcoholic fatty liver patients were divided into two groups by random number table method with 60 cases in each,control group was given the liver lipid lowering drugs,lifestyle and other conventional treatment,observation group was treated with polyene phosphatidyl choline on the basis of the control group,treatment for 3 months,the curative effect in two groups was compared.Results The triglyceride (TG),total cholesterol (T C),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),alanine aminotransferase (ALT),aspartate aminotransferase (AST) and gamma glutamine transferase (GGT) after treatment in two groups were significantly improved than those before treatment [contwl group:(2.4 ±0.6) mmol/L vs.(3.3 ± 1.3) mmol/L,(4.4 ± 1.4) mmol/L vs.(2.2 ± 1.0) mmol/L,(3.0 ± 0.5) mmol/L vs.(3.5 ± 0.8) mmol/L,(1.3 ± 0.6) mmol/L vs.(0.9 ± 0.5) mmol/L,(42.3 ± 11.5) U/L vs.(109.7 ± 36.8) U/L,(40.8 ±7.4) U/L vs.(49.8 ±9.8) U/L,(54.2 ± 12.3) U/L vs.(63.4± 15.7) U/L; observation group:(1.1 ± 0.4) mmol/L vs.(3.3 ± 1.1) mmol/L,(6.1 ± 1.5) mmol/L vs.(2.3 ± 1.1) mmol/L,(2.6 ± 0.4) mmol/L vs.(3.6 ± 0.9) mmol/L,(1.7 ± 0.7) mmol/L vs.(0.9 ± 0.6) mmol/L,(78.6 ± 19.8) U/L vs.(112.1 ±41.1) U/L,(30.2 ±7.8) U/L vs.(51.2 ± 11.3) U/L,(42.7 ±9.8) U/L vs.(66.8 ± 14.6) U/L],and the differences were statistically significant (P ＜ 0.05),and observation group was better than control group,and the differences were statistically significant (P ＜ 0.05).The total effective rate in observation group was higher than that in control group [93.3％(56/60) vs.76.7％(46/60)],and the difference was statistically significant (P ＜ 0.05).Compared with before treatment,the physical health,mental health,social health in two groups were significantly improved [control group:(135.6 ± 21.2) scores vs.(127.8 ± 18.9) score,(121.9 ± 16.9) scores vs.(110.2 ± 13.6) scores,(85.8 ± 12.1) scores vs.(78.9 ± 11.1) scores;observation group:(149.4 ±20.2) scores vs.(128.1 ±21.9) scores,(142.3 ±23.1) scores vs.(108.9 ± 12.8) scores,(94.1 ± 15.3) scores vs.(80.2 ± 13.5) scores],and the differences were statistically significant (P ＜0.05),and observation group was better than control group,and the difference was statistically significant (P ＜0.05).Conclusions Polyene phosphatidyl choline combined with lifestyle intervention in treatment of non-alcoholic fatty liver has obvious curative effect,which can significantly improve the liver function and improve the quality of life of patients,it is safe and effective method in treatment of patients with non-alcoholic fatty liver and worthy clinical promotion. Key words: Phosphatidylcholines; Life style; Fatty liver; Treatment outcome; Quality of life