Abstract
Rheumatic immune disease is a kind of disease caused by the abnormal of autoimmune system, the pathogenesis is complex and affected by many factors. Matrix metalloproteinases are a kind of proteolytic enzyme that can degrade extracellular matrix components, while the matrix metalloproteinase3 is the main enzyme that promote their degradation. In recent years, studies have found that matrix metalloproteinase-3 participates in the development of rheumatic immune disease. It is a potential marker not only can reflect the activity of some diseases, but also to evaluate therapeutic effect. Key words: Autoimmune diseases; Rheumatic diseases; Matrix metalloproteinase 3; Tissue inhibitor of metalloproteinases; Biomarkers
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