Clinical value of intranasal dexmedetomidine combined with intravenous propofol for analgesia during enteroscopy in children

Abstract

Objective To compare the effect and safety of propofol with intranasal dexmedetomidine in analgesic enteroscopy for children. Methods Ninety children undergoing analgesic enteroscopy were randomly assigned to 3 groups. Intranasal dexmedetomidine followed by propofol was administered in the observing group; sufentanil and followed by propofol was intravenously given to the control group A; propofol was given to the control group B. The scale of anesthetic effect, HR, RR, MAP and SpO2 30 min after intranasal administration were monitored. The intranasal sedation satisfaction rate, the dose of propofol, wake-up time, hospitalization, hemodynamics, adverse reaction and complication after anesthesia were recorded. Results Intranasal sedation satisfaction rate of the observing group was 83.3%(25/30). The anesthetic effect in observing group(excellent/good/bad: 24/6/0) showed no significant difference from that in the control group A(excellent/good/bad: 25/5/0), but better than that in the control group B(excellent/good/bad: 12/14/4)(P<0.05). The amount of propofol in the observing group(96.2±5.3)mg showed no significant difference from that of group A(93.7±4.6)mg, but less than group B[(121.1±4.9)mg, P<0.05]. The time of recovery of infants in the control group A[(14.2±5.5)min] and the control group B[(13.7±3.9)min] were longer than that in observing group[(7.9±4.1)min, P<0.05]. The hospitalization time of observing group[(14.3±5.4)min] was shorter than those of group A[(27.5±3.7)min, P<0.05] and group B[(26.3±6.6)min, P<0.05]. The incidences of breath suppression, glossoptosis, nausea and dizziness were the lowest in the observing group, compared with the two others (all P<0.05). Conclusion Intranasal dexmedetomidine combined with propofol, increasing children compliance, decreasing the adverse reaction, is satisfactory and safe for children anesthesia. Key words: Child; Colonoscopy; Anesthesia; Dexmedetomidine; Propofol; Intranasal drop