Clinical value of early continuous renal replacement therapy for patients with acute severe pancreatitis

Abstract

Objective To investigate the therapeutic value of early continuous renal replacement therapy (CRRT) for patients with acute severe pancreatitis (SAP). Methods Eighty-two patients with SAP treated in the First Hospital of Shanxi Medical University from March 2016 to March 2019 were enrolled. The patients were divided into the control group and the observation group according to the order of admission, with 41 cases in each group. Patients in the control group received routine comprehensive treatment, and patients in the observation group received early CRRT treatment. The treatment outcomes of the two groups were analyzed. Results There was no significant difference in the scores of Apache II or visual analogue scale (VAS) between the two groups (P>0.05). The scores of Apache II and VAS were decreased in bothe groups 3 days after treatment, and the decreases and intensive care unit time in the observation group were superior to those in the control group (P all 0.05). However, the levels of TNF-α, IL-1β and AMS in the observation group were better than those in the control group, and the decrease in observation were greater 3 days after treatment (P all<0.05). The incidences of acute lung injury/acute respiratory distress syndrome (19.51%), mechanical ventilation (21.95%), and death (4.88%) was significantly lower than those of the control group, which were 51.22%, 58.54%, 24.39%, respectively, and the difference were significant (P<0.05). Conclusions The early CRRT treatment for SAP patients is effective, and it is beneficial to the prognosis. Key words: Renal replacement therapy; Acute severe pancreatitis; Application value