Abstract
The results of the survey of 214 patients with the complicated pregnancy (a preeclampsia, a premature detachment of placenta, antenatal fetal death, miscarriage) in the anamnesis are presented in the article. We determined the level of molecular markers of a thrombophilia (TAT, D-dimer) and aggregation activity of platelets and carried out antithrombotic therapy to these women. It is shown that 47,7 % of such nonpregnant women and pregnant early terms have the high level of D-dimer, TAT - 46,7 %, aggregation activity of platelets - 52,6 %. Determination of the increased levels of molecular markers of a thrombophilia is the indication to application the antithrombotic therapy and allow to control efficiency of this therapy.
Highlights
Clinical value of determination of markers of a thrombophylia at patients with the complicated pregnancy in the anamnesis
■ The results of the survey of 214 patients with the complicated pregnancy in the anamnesis are presented in the article
We determined the level of molecular markers of a thrombophilia (TAT, D-dimer) and aggregation activity of platelets and carried out antithrombotic therapy to these women
Summary
Clinical value of determination of markers of a thrombophylia at patients with the complicated pregnancy in the anamnesis. Показанием к применению противотромботических препаратов у беременных служат выявление генетических маркеров тромбофилии — генетических мутаций и полиморфизмов, способствующих активации системы свертывания крови и/или циркуляции антифосфолипидных антител (АФА) [2]. Ответить на эти вопросы помогает гемостазиологическое исследование с определением уровней молекулярных маркеров тромбофилии и агрегационной активности тромбоцитов.
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