Abstract
BackgroundSevere acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is threatening the world with the symptoms of seasonal influenza. This study was conducted to investigate the patient characteristics and clinical value of blood markers to assess the severity of coronavirus disease 2019 (COVID-19).Methods187 patients, diagnosed with COVID-19 (non-severe and severe cases) and admitted to hospital between January 27th and March 8th of 2020, were enrolled in the present study.ResultsA higher proportion of clinical symptoms, including cough, expectoration, myalgia, and fatigue were observed in the non-severe group. The level of white blood cell count, neutrophils, CRP, IL-6 and IL-8 were significantly increased, while the platelet count was remarkedly decreased in the severe group. The risk model based on lymphocyte, IL-6, IL-8, CRP and platelet counts had the highest area under the receiver operator characteristic curve (AUROC). The baseline of IL-6, IL-8 and CRP was positively correlated with other parameters except in the cases of lymphocyte, hemoglobin and platelet counts. The baseline of the platelet count was negatively correlated with other parameters except in the lymphocyte and hemoglobin counts. Additionally, there was no connection between the severity of COVID-19 and cultures of blood, sputum or catheter secretion.ConclusionsThe present study suggested that high leucocyte and low platelets counts were independent predictive markers of the severity of COVID-19.
Highlights
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is threatening the world with the symptoms of seasonal influenza
Based on current epidemiological investigation, over 2 million people worldwide have been affected by COVID-19 [3], which has shown to excess the outbreak of severe acute respiratory syndrome (SARS) in 2002 and middle east respiratory syndrome (MERS) in 2012 [7], undermining the global economy, and destabilizing societies across the
Higher levels of inflammatory markers were associated with severe disease: leukocyte, p = 0.001; neutrophils, p < 0.001; C-reaction protein (CRP), p = 0.021; interleukin-6 (IL-6), p = 0.031; and, interleukin-8 (IL-8), p = 0.007
Summary
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is threatening the world with the symptoms of seasonal influenza. This study was conducted to investigate the patient characteristics and clinical value of blood markers to assess the severity of coronavirus disease 2019 (COVID-19). The coronavirus disease in China, that began in December 2019 (COVID-19), is an emerging lethal respiratory disease and has threatened global health [1, 2]. Based on current epidemiological investigation, over 2 million people worldwide have been affected by COVID-19 [3], which has shown to excess the outbreak of severe acute respiratory syndrome (SARS) in 2002 and middle east respiratory syndrome (MERS) in 2012 [7], undermining the global economy, and destabilizing societies across the. A novel vaccine of COVID-19 is being conducted for clinical trials, which might make a great progress for the further treatments
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