Clinical value of blood lipid, serum β2-microglolulin and tumor necrosis factor-α level in patients with acute leukemia

Abstract

Objective To study on diagnosis value of blood lipid, serum β2-microglolulin(β2-MG) and tumor necrosis factor-α(TNF-α) in acute leukemia. Methods The serum β2-MG and TNF-α(with radioimmunoassay) blood lipid(with biochemistry) levels were determined in 123 patients with acute leukemia as well as 36 controls, then conducted the correlative tests. Results Serum β2-MG、TNF-α and triglyceride levels in 123 patients including 46 patients with acute monocytic leukemia, 32 patients with acute lymphocytic leukemia and 45 patients with acute nonlymphocytic leukemia were significantly higher than those in 36 controls(t =4.123 -6.815, P＜0.01). The serum lipoprotein (α) level was tightly increased (t=1.345, t=1.421,t=1.381, P＞0.05); The serum cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, apolipoprotein A levels in 123 patients with acute leukemia were significantly lower than those in 36 controls( t=2.110-2.574, P＜0.05), the serum apolipoprotein B level was tightly lowed (t=1.261, t=1.381, t=1.456, P＞0.05). Conclusion The determination of blood lipid, serum β2-MG and TNF-α level might be useful for diagnosing acute leukemia and reflecting the prognostic value. Key words: Leukemia; Beta 2-microglolulin; Tumor necrosis factor-alpha; Lipoproteins; Apolipoproteins