Clinical value of Bi-parametric prostate MR and PSA-density in diagnosis of prostate cancer

Abstract

Objective Prostate specific antigen density (PSAD) and bi-parametric magnetic resonance imaging (BPMR) in the detection of early prostate cancer. The purpose of this study is to evaluate the diagnostic value of single detection of PSAD, dual-parameter prostate magnetic resonance or combined detection in patients with prostate cancer. Methods We retrospectively studied 169 patients who prostate biopsy and all underwent prostate MRI before biopsy. We recorded the results of PSAD and two-parameter prostate magnetic resonance imaging (consisting of T2WI and DWI sequences) in each patient were recorded, and then the clinical value of PSAD and two-parameter prostate magnetic resonance imaging (bp-MR) in the early diagnosis of prostate cancer by regression curve and logistic regression analysis were evaluated. Results In all evaluated scenarios, The area under ROC curve for PI-RADS was(0.890±0.027), The area under ROC curve for PI-RADS was (0.843±0.031), The area under ROC curve for their combination was (0.932±0.020). The diagnostic sensitivity of PSAD, PI-RADS and their combination were 67.4%, 84.3%, 84.3%, the specificity of PSAD、PI-RADS and their combination were 90.0%, 91.2%, 87.5%. Conclusions The predictive effect of bp-MR for prostate cancer is significantly stronger than that of PSAD, and the combination of PSAD and bp-MR can significantly improve the clinical diagnostic efficiency of early prostate cancer. Key words: Prostatic Neoplasms; Prostate-Specific Antigen; Magnetic Resonance Imaging