Abstract
BackgroundCystatin C has been proposed as a novel marker of renal function and predictor of cardiovascular risk. The aim of this study was to investigate the role of cystatin C level as a predictor of cardiovascular events in patients with coronary artery disease (CAD).MethodsThree hundred and five coronary artery patients were included in this study. Serum cystatin C levels, high‐sensitive C‐reactive protein (hs‐CRP), and oxidative stress were measured. Estimated glomerular filtration rate (eGFR) and the CAD severity score were calculated.ResultsCystatin C was correlated with the CAD severity score (r = 0.631, P < 0.0001) and was significantly elevated in the CAD severity score >50. Every 0.1 mg/l increase in cystatin C, 2 mg/l increase in hs‐CRP, 0.2 mmol/l decrease in high‐density lipoprotein cholesterol, 13.7 ml/min decrease in eGFR, and 1.51 μmol/l increase in homocysteine caused a 34, 12, 5, and 22% increase in the risk of having CAD, respectively.ConclusionCystatin C could be a useful laboratory biochemical marker in predicting the severity of CAD. Cystatin C is associated with biochemical atherosclerosis markers such as CRP and homocysteine.
Highlights
Renal function has been identified as a risk factor for the onset and prognosis of coronary artery disease (CAD, [1])
We studied 305 patients grouped according to the CAD severity score
Cystatin C concentration was significantly elevated in the patients with a CAD severity score >50% compared to the normal coronary artery patients (2.9 ± 2.2 mg/l vs. 0.7 ± 0.2 mg/l)
Summary
Renal function has been identified as a risk factor for the onset and prognosis of coronary artery disease (CAD, [1]). In practice, since GFR is usually not directly measured in routine clinical practice, markers such as creatinine are used to estimate GFR. Estimating equations such as the Cochroft-Gault equation [3] or the modification of diet in renal disease (MDRD, [4]) study equation are widely used for this purpose. Cystatin C has been proposed as a novel marker of renal function and predictor of cardiovascular risk. The aim of this study was to investigate the role of cystatin C level as a predictor of cardiovascular events in patients with coronary artery disease (CAD).
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