Clinical utility of glutathione-S-transferases, Alkaline Phosphatase and Lactate Dehydrogenase activity in oesophagus cancer patients before and after chemotherapy for Diagnosis and Prognosis

Abstract

Purpose: - To analyze the level of serum glutathione-s-transferases (GSTs), Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH) activity in patients of oesophagus cancer before and after chemotherapy. Methods: - For the study total 50 cases of carcinoma of oesophagus of stage II and stage III (after and before chemotherapy) were selected. All patients were clinically and histological diagnosed. 40 age and sex matched healthy normal subjects selected as control. GSTs, ALP, and LDH activity was measured in the serum of control group (n=40) and in patients with oesophagus cancer (n=50). Results: -Mean GSTs, ALP, and LDH activity in serum was significantly higher in patients with oesophagus cancer as compared to control group (p<0.001). The patients of oesophagus cancer after chemotherapy had significantly elevated activity of serum GSTs, ALP, and LDH than before chemotherapy. Conclusion: - Measurement of serum GSTs, ALP and LDH activity may be useful as a tumor marker in oesophagus cancer. Alterations in serum GSTs levels might be helpful to predict the response of chemotherapy. LDH and ALP are good indicator of stages and bulk of tumor LDH is also a good prognostic factor in advanced