Clinical utility of a novel index to predict systolic dysfunction and adverse clinical outcome in patients with acute ST-elevation myocardial infarction: a pilot study

Abstract

Purpose: We proposed a new index Area Flow Index (AFI) to predict initial area-at-risk in patients with anterior myocardial infarction. The aim of the study is to assess the predictive role of AFI for reduction in systolic function and its relation to adverse clinical outcomes. Methods: One-hundred-sixty-seven acute anterior wall MI patients treated with primary PCI were enrolled to the study. AFI was calculated by dividing culprit segment cross-sectional area (CSA) to total coronary CSA (Fig. 1). Patients were evaluated with echocardiography for LV systolic function 5-7 days after MI. Results: There was a significant negative correlation between AFI and LVEF (r=-0.59, p 28.4% had a 75.6% sensitivity and 78.1% specificity for predicting severe LV dysfunction. Composite 1-month MCE were higher in the group with AFI >28.4% (p=0.01). View this table: Table 1. Clinical characteristics in different LVEF groups ![Figure][1] Figure 1. Calculation of AFI. Conclusion: Simple index derived from coronary angiography at time of primary PCI can predict LV systolic function loss and adverse clinical outcome in patients with acute anterior myocardial infarction. [1]: pending:yes