Abstract
Gamma-aminobutyric acid is the brain's main inhibitory neurotransmitter and has already been implicated in the pathophysiology of epilepsy by several investigations. A selective antagonist of GABAA-benzodiazepine receptors, which is frequently used, is the radioligand 11C Flumazenil. In patients with intractable focal epilepsy a localized reduction in (11C) FMZ binding is demonstrated, which correlates closely with the area of seizure onset.
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