Clinical utility and tolerability of JSPH-1 wireless esophageal pH monitoring system

Jun-Nan Li,Chun-Lun Liu,Xiao-Hong Tao

doi:10.1186/1471-230x-13-10

Abstract

BackgroundWireless esophageal pH monitoring system is an important approach for diagnosis of gastroesophageal reflux disease (GERD), the aim of this study is to test the tolerability and utility of the first wireless esophageal pH monitoring system made in China, and evaluate whether it is feasible for clinical application to diagnose GERD.MethodsThirty patients from Department of Gastroenterology of The First Affiliated Hospital of Chongqing Medical University who were suspected GERD underwent JSPH-1 pH capsule. The capsule was placed 5 cm proximal to the squamocolumnar junction (SCJ) by endoscopic determination, the data was recorded consecutively for 48 hours. Then all pH data was downloaded to a computer for analysis. The discomforts reported by patients were recorded.Results30 patients were placed JSPH-1 pH capsule successfully and completed 24-hour data recording, 29 patients completed 48-hour data recording. One patient complained of chest pain and required endoscopic removal. No complications and interference of daily activities were reported during data monitoring or follow-up period. 48-hour pH monitoring detected 15 patients of abnormal acid exposure, on day1 detected 9 patients, the difference had statistical significance (P<0.01). Positive symptom index (SI) was identified in 3 patients with normal pH data in both 24-hours. In total, 48-hour monitoring increased diagnosis of GERD in 9 patients.Conclusion48-hour esophageal pH monitoring with JSPH-1 wireless pH monitoring system is safe, well tolerated and effective. It can be feasible for clinical application to diagnose GERD.

Highlights

Wireless esophageal pH monitoring system is an important approach for diagnosis of gastroesophageal reflux disease (GERD), the aim of this study is to test the tolerability and utility of the first wireless esophageal pH monitoring system made in China, and evaluate whether it is feasible for clinical application to diagnose GERD
JSPH-1pH capsule system Materials of the JSPH-1 pH wireless monitoring system include a capsule, a delivery device and a wireless data receiver (Figure 1), a capsule by the size of 26.5 mm×6.0 mm×5.5 mm, the container constructed with acid–resistant and alkali–resistant material, containing an antimony pH electrode, a silver oxide internal battery, a radio transmitter and a clipping device (Figure 2)
Symptoms related to capsule attachment were: foreign body sense in 12(40%), chest pain in 10 (33%), dysphagia in 8(27%), and 5(17%) had more than one symptom

Summary

Introduction

Wireless esophageal pH monitoring system is an important approach for diagnosis of gastroesophageal reflux disease (GERD), the aim of this study is to test the tolerability and utility of the first wireless esophageal pH monitoring system made in China, and evaluate whether it is feasible for clinical application to diagnose GERD. Esophageal pH monitoring serves an important role in numerous methods, because it can quantify esophageal acid exposure and provide objective pH data for diagnosis. Patients would like to keep more sedentary during monitoring period, and modify normal activities/or diet which may provoke acid reflux [3,4]. Movement of catheter can lead electrode off the primary position. All of this can result in inaccurate pH data and final diagnosis

Objectives

Methods

Results

Conclusion