Abstract
Nuclear medicine imaging of infection has two major indications: localization of a focus of infection in patients with fever of unknown origin; and the diagnosis of an infection in patients with localized symptoms, for example after surgery, when normal anatomy is absent or when metal implants prevent computed tomography or magnetic resonance imaging. Here we present the use of Tc-99m-mononuclear leukocytes in the imaging of 29 patients with infectious lesions (27 in hip prothesis and two in lumbar spine). Autologous cells were labeled using a simple technique with stannous chloride and Tc-99m-mononuclear leukocytes, previously described by us. The labeled cells were administered (444 MBq) and scans were carried out 1, 3 and 24 hours after injection. There were two cases where scintigraphies were negative and the biopsies were positive for infectious hip. All remaining cases were positive, indicating infections were present. These results may determine the future of this challenging and fascinating field and the role of nuclear medicine in the management of patients with infection/inflammation.
Highlights
Cardiac surgery with cardiopulmonary bypass (CPB) is a recognized trigger of systemic inflammatory response, usually related to postoperative acute lung injury (ALI)
In 14 patients, bone marrow was harvested from iliac crest and Bone marrow-derived mononuclear cell (BM-MNC) were selected by Ficoll gradient
The objective was to evaluate the characteristics of Chest pain (CP) in patients with acute aortic dissection (AAD) admitted in a chest pain unit (CPU)
Summary
Cardiac surgery with cardiopulmonary bypass (CPB) is a recognized trigger of systemic inflammatory response, usually related to postoperative acute lung injury (ALI). Few studies exist analysing the handling of acute respiratory insufficiency with invasive mechanical ventilation (IMV) and its correlation with mortality among the elderly intensive care unit (IUC) patient population. In Brazil, most patients with TBI are managed in general ICUs. The results of the treatment of patients admitted to nonspecialized ICUs must be compared with those obtained in neurosurgical ICUs. An acute confusional state (ACS) has been a frequent finding in patients undergoing cardiac surgery (CS), which, according to the literature, has resulted in a greater number of complications and in an increase in hospitalization and length of stay in the intensive care unit (ICU). The mortality of elderly patients who are admitted to intensive care units (ICU) has been the aim of some recent studies. Drugs that modulate such phenotypic alterations may be useful in the control of these and other clinical situations
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