Abstract
Purpose. This study was to report the clinical use of biomimetic nanohydroxyapatite/polyamide 66 (n-HA/PA 66) mesh cages in anterior cervical corpectomy and fusion (ACCF) surgery.Method. 95 patients who underwent single level anterior cervical corpectomy and fusion for cervical spondylosis myelopathy (CSM) in our hospital were reviewed and divided into 2 groups according to using nanohydroxyapatite/polyamide mesh cage and titanium mesh cage (TMC). Demographic data of patients and surgical, clinical, and radiological data before operation and at last follow-up were collected and compared.Result. The operation time, surgical blood loss, complications, and Japanese Orthopaedic Association scores (JOA scores) of two groups were similar. At the last follow-up both the two groups obtained 100% solid bone fusion, but the TMC group had higher rate of severe cage subsidence than the n-HA/PA 66 group (27% versus 2%).Conclusion. Nanohydroxyapatite/polyamide 66 mesh cage is safe and effective in ACCF and can be a substitution to titanium mesh cage.
Highlights
Nanohydroxyapatite/polyamide 66 (n-HA/PA 66) is a biocomposite made by nanotechnology using hydroxyapatite and polyamide [1]
The last follow-up Japanese Orthopedic Association (JOA) scores of both groups improved significantly compared to preoperative JOA scores
Allografts, and cages are used as support structure implant in ACCF
Summary
Nanohydroxyapatite/polyamide 66 (n-HA/PA 66) is a biocomposite made by nanotechnology using hydroxyapatite and polyamide [1]. Nanotechnique is popular in biomaterial field and is widely accepted by researchers [2,3,4]. Hydroxyapatite (HA) and natural bone mineral have similar composition and structure, so HA was considered as an ideal bone repair material due to its osteoconductivity. The brittleness of HA decide that it only can be used in no load-bearing bone repair. Because chemical structure and active groups of polyamide (PA) are similar to collagen protein, it has good biocompatibility. N-HA/PA 66 composite combined the advances of the two materials. It was considered as an ideal material in bone defect repair and reconstruction
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