Abstract
目的 观察可调钠透析(PHD)在透析患儿中应用的安全性,确证PHD是否对儿童血液透析的并发症有预防作用以及是否会增加患儿的钠负荷.方法 28例血液透析(HD)的肾功能衰竭患儿,年龄1.3～15.1岁(男11例,女17例),其中6例应用普通透析(CHD),匀速脱水;4例应用PHD,脱水先快后慢;18例患儿应用了2种透析方法 ;共进行HD 319例次,其中PHD 129例次,CHD 190例次.结果 PHD和CHD两组间透析前、后血钠浓度、尿素氮、肌酐、渗透压及钠清除差异均无显著性(P＞0.05).PHD组中低血压和失衡综合征的患病率分别为5.4%和9.3%,明显低于CHD组的12.1%和17.9%(P＜0.05).结论 PHD结合先快后慢的程序超滤与CHD相比,在毒素清除率相同的基础上可减少透析低血压和失衡综合征的患病率,有更好的血容量维持作用,且不伴有钠负荷的增加。
Published Version
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