Abstract
The aim of the present study was to investigate of the therapeutic efficacy of the two- components antimicrobial drug. The drug contains two antimicrobial components that act synergistically. Acute intestinal infection of calves was treated. The drug was given with food. The dose and method of administration were determined by the manufacturer. Before use, the sensitivity of pathogenic microorganisms to the active components of the drug was determined. During the experiment, constant monitoring of the clinical condition and physiological parameters of the organism of experimental animals was performed.
 Evaluation of hematological and biochemical parameters of the body was performed according to recognized methods. Therapeutic efficacy was compared with data obtained using the reference drug. The obtained data were processed statistically. Based on the obtained data, conclusions were made about the effectiveness of treatment and the effect of the drug on the body of young cattle.
 According to the assessment of the clinical condition of the animals and the results of laboratory studies, it was found that the tolerability of the study drug for the treatment of intestinal infections in young animals was good. During the experimental period and two weeks after the use of drugs, no side effects were detected and no changes in the behavior of calves were observed. The therapeutic efficacy of the study drug was 100 %, and the recovery period was 5 days. Comparative analysis of hematological parameters of calves showed a significant decrease in the percentage of rod-shaped neutrophils in the leukogram of sick animals after antibiotic therapy. Normalization of the leukogram indicated the cessation of inflammatory processes and improvement of the physiological condition of animals. Analysis of the influence of drugs on biochemical indices in experimental calves showed no changes during the observation period. Negative impact on liver indicators under administration weren't found. Laboratory studies have not revealed nephrototoxic effects of antimicrobial drugs. Confirmed the safety and therapeutic efficacy of the two antimicrobial components drug.
Highlights
Оцінку гематологічних та біохімічних показників стану організму проводили за визнаними методиками
The aim of the present study was to investigate of the therapeutic efficacy of the twocomponents antimicrobial drug
Therapeutic efficacy was compared with data obtained using the reference drug
Summary
Оцінку гематологічних та біохімічних показників стану організму проводили за визнаними методиками. За оцінкою клінічного стану тварин та отриманими результатами лабораторних досліджень встановлено, що переносимість досліджуваного препарату за лікування кишкової інфекції молодняка була доброю. Протягом дослідного періоду та двох тижнів після застосування препаратів не виявлено побічної дії і не зауважено змін в поведінці телят. Порівняльний аналіз гематологічних показників телят показав достовірне зниження відсотка паличкоядерних нейтрофілів у лейкограмі хворих тварин після проведеної антибіотикотерапії.
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