Abstract
BackgroundPreeclampsia (PE) is a common maternal disease that complicates 5 to 10% of pregnancies and remains as the major cause of maternal and neonatal mortality. Cost-effective interventions aimed at preventing the development of preeclampsia are urgently needed. However, the pathogenesis of PE is not well known. Multiple mechanisms such as oxidative stress, endothelial dysfunction and insulin resistance may contribute to its development. Regular aerobic exercise recovers endothelial function; improves insulin resistance and decreases oxidative stress. Therefore the purpose of this clinical trial is to determine the effect of regular aerobic exercise on endothelial function, on insulin resistance and on pregnancy outcome.Methods and design64 pregnant women will be included in a blind, randomized clinical trial, and parallel assignment. The exercise group will do regular aerobic physical exercise: walking (10 minutes), aerobic exercise (30 minutes), stretching (10 minutes) and relaxation exercise (10 minutes) in three sessions per week. Control group will do the activities of daily living (bathing, dressing, eating, and walking) without counselling from a physical therapist.Trial registrationNCT00741312.
Highlights
Preeclampsia is a disease of worldwide distribution, which complicates 5% to 10% of pregnancies and remains as the major cause of maternal and neonatal mortality and morbidity [1,2]
In Colombia the high incidence of preeclampsia (5.1%), low birth weight (LBW; 13.2%), intrauterine growth restriction (IUGR; 7.9%) and perinatal mortality (3.68 per 1000 live births) is considered a serious public health problem that needs to be solved [3,4,5]. Multiple conditions such as maternal age, nulliparity, previous personal and family history of PE, poor nutrition, sedentary life styles, residence at high altitudes, and lack of adequate prenatal care have been associated with an increased risk for PE
General objective To determine the effect of regular aerobic exercise on endothelium-dependent brachial artery flow-mediated dilatation, insulin resistance and pregnancy outcome
Summary
64 pregnant women will be included in a blind, randomized clinical trial, and parallel assignment.
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