Clinical Trial of the Hypotensive Combination : Dihydroergocristine, Clopamide and Reserpine. (A Multicentre Cooperative Double Blind Study)

Abstract

A multiclinical cooperative clinical trial at three university clinics in Tokyo is described. The three components of an anti-hypertensive combination have been compared with placebo in double blind fashion alone and in the possible combinations. [Formula: see text] The patients were treated with flexible doses during four weeks (max dose 3 caps/day). For statistical evaluation 159 patients were available. In mild to moderate hypertension the combination of the three components caused, in lower doses, a significantly greater blood pressure reduction than the components separately or combinations of two. No important side-effects were encountered.