Abstract
The Clinical Trial Design and Development Working Group within the Quantitative Imaging Network focuses on providing support for the development, validation, and harmonization of quantitative imaging (QI) methods and tools for use in cancer clinical trials. In the past 10 years, the Group has been working in several areas to identify challenges and opportunities in clinical trials involving QI and radiation oncology. The Group has been working with Quantitative Imaging Network members and the Quantitative Imaging Biomarkers Alliance leadership to develop guidelines for standardizing the reporting of quantitative imaging. As a validation platform, the Group led a multireader study to test a semi-automated positron emission tomography quantification software. Clinical translation of QI tools cannot be possible without a continuing dialogue with clinical users. This article also highlights the outreach activities extended to cooperative groups and other organizations that promote the use of QI tools to support clinical decisions.
Highlights
The Quantitative Imaging Network (QIN) program under the National Cancer Institute (NCI) is chartered to improve clinical decision-making by developing and validating quantitative imaging (QI) methods including data acquisition and analysis methods to support the measure and prediction of tumor response to therapy [1]
The QIN brought together multidisciplinary teams under the governance of the Executive Committee comprising QIN principal investigators and the Coordinating Committee with leaders from three working groups (WGs) (Figure 1). These WGs are tasked with addressing problems encountered in Clinical Trial Design and Development (CTDD), Bioinformatics and Data Sharing (BIDS), and Image Analysis and Performance Metrics (IAPM), with subgroups focusing on positron emission tomography computed tomography (PET-CT) and magnetic resonance imaging (MRI)
We summarize the activities and challenges of the CTDD working group (CTDDWG) in the past 10 years
Summary
Clinical Trial Design and Development Work Group Within the Quantitative Imaging Network.
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