Abstract
Objectives/Aims:To evaluate continuous and episodic twice-daily usage regimens of a desensitising dentifrice containing 5% calcium sodium phosphosilicate (CSPS).Materials and Methods:In this exploratory, single-centre, randomised, examiner-blind study, subjects with dentinal hypersensitivity were randomised to continuous (24 weeks) use of a 5% CSPS-containing dentifrice or episodic use of the dentifrice comprising two 8-week treatment periods separated by 8 weeks′ use of a standard fluoride dentifrice. Sensitivity was assessed by tactile threshold (Yeaple probe) and evaporative (air) sensitivity (Schiff sensitivity score). Other measures included labelled magnitude scales to assess subjects′ responses to the evaporative stimulus, the Dentine Hypersensitivity Experience Questionnaire and a tooth sensitivity question.Results:Seventy-six subjects were randomised to continuous (n=38) or episodic (n=38) use. Small but statistically significant improvements from baseline in Schiff sensitivity scores were observed at weeks 8, 16 and 24 with both regimens (all P<0.05). Increases from baseline in tactile threshold were not statistically significant. No significant between-regimen difference was observed for any endpoint. No treatment-related adverse events were reported.Discussion:Dentifrice containing 5% CSPS improved dentinal hypersensitivity with both episodic and continuous twice-daily usage regimens over 24 weeks and was well tolerated.Conclusion:No performance differences were observed between the two usage regimens.
Highlights
Dentinal hypersensitivity is a common oral condition characterised by pain derived from exposed dentine in response to chemical, thermal, tactile or osmotic stimuli, which cannot be accounted for by any other dental defect or disease.[1,2,3] Hypersensitivity develops as a result of gingival recession, and/or erosion and abrasion of enamel, leading to exposure of the underlying dentine.[4]
Calcium sodium phosphosilicate (CSPS; Novamin, GSK Consumer Healthcare, Weybridge, UK) is a particulate, bioactive material incorporated into oral healthcare products indicated for the treatment of dentinal hypersensitivity
The efficacy of dentifrices containing 5% CSPS in reducing dentinal hypersensitivity has been demonstrated in randomised controlled clinical studies of up to 8 weeks′ duration.[16,17,18,19,20,21,22,23,24,25]
Summary
Dentinal hypersensitivity is a common oral condition characterised by pain derived from exposed dentine in response to chemical, thermal, tactile or osmotic stimuli, which cannot be accounted for by any other dental defect or disease.[1,2,3] Hypersensitivity develops as a result of gingival recession, and/or erosion and abrasion of enamel, leading to exposure of the underlying dentine.[4]. Treatments for dentinal hypersensitivity are generally based on one of two approaches—the use of depolarising agents, such as potassium ions, with the aim of blocking neural transmission of the pain stimulus, or the use of tubule-occluding agents that physically block exposed dentinal tubules These blocking agents include strontium, oxalate or stannous salts; arginine; bioglasses; and silicas, which serve to seal the dentine tubules, thereby reducing dentinal-fluid movement in response to external stimuli.[6,7,8,9,10,11] Calcium sodium phosphosilicate (CSPS; Novamin, GSK Consumer Healthcare, Weybridge, UK) is a particulate, bioactive material incorporated into oral healthcare products indicated for the treatment of dentinal hypersensitivity. In vitro studies of CSPS-containing dentifrices have demonstrated maintenance of the occlusive layer following exposure to dietary acid.[26]
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