Clinical study on treatment efficacy of malignant eosinophilic granuloma of orbit in 15 children

Abstract

Objective To study clinical character and analysis efficacy of orbit malignant eosinophilic granuloma for first symptom with orbit mass in children. Methods A total of 15 patients with orbit malignant eosinophilic granuloma in children were diagnosed using pathology hospital from Apr.2007 to Apr.2013(11 cases of male, 4 cases of female). The median age was 2.25 years old(1-12 years). In 15 cases, 4 cases of chemotherapy using MVP project [methylamine (M)+ vincristine(V)+ prednisone(P)], and 11 cases of chemotherapy using DAL-HX 83/90 project [etoposide (VP-16)+ prednisone+ vinblastine]. Thirteen cases were treated by using surgery and chemotherapy, and 2 cases were treated using single chemotherapy.Statistics analysis clinical characters, efficacy and prognosis of 15 cases of malignant orbit eosinophilic granuloma in children. Results 1.First symptom: 13 cases of orbit mass and extruded with eyeball(86.7%), 3 cases of strabismus and diminution of vision and eyes pain(13.3%), and no fever of all patients.2.Eye of the disease come on: right orbit was 7 cases, accounted for 46.7%, and left orbit was 8 cases, accounted for 53.3%.3.Follow up to Oct.2013, median time was 17 months (8-71 months), 15 cases were followed.The niduses of 13 cases were complete absorbed, the niduses of 2 cases were most absorbed.In 15 cases, no patient was relapse.Five patients with strabismus and diminution of vision and eyes pain were recover after chemotherapy and no function obstruction. Conclusions Malignant orbital eosinophilic granuloma in children insidious onset, and atypical clinical manifestations, should pay attention to the differential diagnosis.Orbital eosinophilic granuloma in children sensitive to chemotherapy.The focus absorption rate by comprehensive treatment and follow-up is higher. Key words: Eosinophilic granuloma; Orbit; Chemotherapy; Surgery; Child