Abstract
Diabetic foot ulcers (DFUs) have a high disability rate and have a great impact on patients and society, and the search for effective and economical treatment options is a major clinical concern. In this study, 112 patients with DFU admitted to two hospitals from October 2018 to November 2020 were randomly divided into 56 cases each in the single group treated with Prontosan gel dressing and the joint group treated on silver ion dressing combined with Prontosan gel dressing. Both groups of patients were evaluated for efficacy after 30 days of treatment. The number of days for debridement, granulation tissue growth time, epithelial tissue formation time, and wound healing time were observed and recorded in both groups. The trauma area, visual analogue score (VAS), and levels of inflammatory factors such as vascular endothelial adhesion molecule-1 (VCAM-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were recorded before and after treatment in both groups. The occurrence of adverse reactions such as edema, fever, infection, and rash during treatment was recorded in both groups for safety assessment. Comparison of the abovementioned data showed that the clinical efficacy of the joint group was significantly higher than that of the single group. The number of days to clear wounds, granulation tissue growth time, epithelial tissue formation time, and wound healing time were significantly lower in the joint group than in the single group. The trauma area, VAS score, VCAM-1, IL-6, TNF-α, and CRP levels decreased in both groups after treatment compared with the pretreatment levels, with the joint group being lower than the single group. The results also showed that the difference in the overall incidence of adverse reactions between the two groups was not statistically significant, and the incidence was low and transient. In addition to the usual treatment regimen of blood glucose control and improvement of microcirculation for patients with DFU, combined treatment with silver ionomer dressings and Prontosan gel dressings can promote ulcer healing and improve foot wound regression. It has a stronger antibacterial effect and can more effectively reduce the inflammatory response of the ulcerated surface with fewer adverse effects, making it an effective and safe method for the treatment of DFU, and has implications for promotion.
Highlights
Diabetic foot (DF) as one of the serious chronic complications of diabetes mellitus (DM), is the leading cause of hospitalization as well as nontraumatic toe amputation or even amputation in DM patients [1]
The silver ion dressing and Prontosan gel dressing were combined to explore the role of the combination of the two in diabetic foot ulcers (DFUs) treatment through clinical research. e clinical data, treatment, and inflammatory factor levels of DFU patients admitted to our hospital were calculated and analyzed, and it was proposed to investigate the clinical effect of silver ion dressing combined with Prontosan gel in the treatment of DFU
Local inflammatory response is a protective response to a noxious stimulus, but excessive inflammation can exacerbate the damage, and it has been shown that high levels of inflammatory factors are closely associated with the persistence of DFU [17, 18]. e current treatment of DFU includes glycemic control, improvement of microcirculation, improvement of neurological function, topical dressing of the trauma, and revascularisation [19]. e use of topical dressings on the wound is an important aspect of DFU treatment, and studies have shown that early and effective topical dressings can promote ulcer healing and reduce the incidence of amputation [20]
Summary
Diabetic foot (DF) as one of the serious chronic complications of diabetes mellitus (DM), is the leading cause of hospitalization as well as nontraumatic toe amputation or even amputation in DM patients [1]. Silver ion dressing on the ulcerated surface of diabetic foot can form a local antibacterial environment to reduce the chance of bacterial infection and, reduce local secretion, with bactericidal and antibacterial effects and absorption of wound exudate [10, 11]. Prontosan gel has a long-lasting preventive effect against bacterial biofilm, provides moisture to the wound, and can cause autolysis of necrotic tissue in the DF to promote wound healing [12]. Both dressings are widely used in the treatment of DFU and have good results, but there are relatively few reports on the efficacy of their combined application on DFU. The silver ion dressing and Prontosan gel dressing were combined to explore the role of the combination of the two in DFU treatment through clinical research. e clinical data, treatment, and inflammatory factor levels of DFU patients admitted to our hospital were calculated and analyzed, and it was proposed to investigate the clinical effect of silver ion dressing combined with Prontosan gel in the treatment of DFU
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