Clinical Study on the Effectiveness of Three Products in the Treatment of Herpes Simplex Labialis

Hanna Boes,Stefan Zimmer,Mozhgan Bizhang,Vlasios Goulioumis,Anna Wechsler

doi:10.1038/s41598-020-63530-6

Hanna Boes, Stefan Zimmer + Show 3 more

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https://doi.org/10.1038/s41598-020-63530-6

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Journal: Scientific Reports	Publication Date: Apr 15, 2020
Citations: 5	License type: open-access

Affiliation: Witten/Herdecke University

Abstract

Herpes simplex labialis (HSL) is a viral disease that affects the perioral region. No guidelines recommending an effective treatment exist. The treatment of HSL with three different products was examined. Herpatch Serum, a film-forming patch, was compared to Compeed Patches, a set of semiocclusive hydrocolloid patches, and Zovirax Cream (ingredient: 5% acyclovir). In this prospective, randomized, examiner-blind study, 180 patients with recurrent HSL were split into three groups (Compeed: n = 60, Herpatch: n = 60, Zovirax: n = 60) and examined within 24 hours of HSL outbreak (DRKS Registration No.: DRKS00007786). The primary endpoint was healing time. The secondary endpoints were the reaction rate and quality of therapy evaluated by the Clinician’s Global Assessment of Therapy (CGAT) and the Subject’s Global Assessment of Therapy (SGAT) (0 = no response; 10 = excellent response), respectively. There was no significant difference among the healing times for the different products. The mean (95% confidence interval) was 9.67 days (9.11–10.22) for Compeed, 9.30 days (8.75–9.85) for Herpatch, and 9.80 days (9.30–10.30) for Zovirax. The reaction rate and quality of therapy (CGAT and SGAT) of Herpatch were significantly higher than those of Compeed and Zovirax. Within the study limitations, Herpatch proved to be an effective, non-antiviral alternative in the treatment of HSL.

Highlights

Herpes simplex labialis (HSL) is a viral disease that affects the perioral region
Herpes simplex labialis (HSL) is a worldwide infection of the oral and perioral regions caused by an infection with Herpes Simplex Virus type 1 (HSV-1) or, rarely, Herpes Simplex Virus type 2 (HSV-2)
Www.nature.com/scientificreports comfort; 10 = high comfort), functionality (0 = poor functionality; 10 = high functionality), handling (0 = hard handling; 10 = easy handling), and satisfaction (0 = no satisfaction; 10 = high satisfaction) were more in favour of Herpatch (Fig. 6). Within this monocentre, randomized, assessor-blind study, the effectiveness of three different products in the treatment of HSL was evaluated in a total of 180 patients

Summary

Introduction

Herpes simplex labialis (HSL) is a viral disease that affects the perioral region. No guidelines recommending an effective treatment exist. Following the primary infection with HSV-1, the virus replicates at the site of infection and proceeds to travel retrograde down unmyelinated sensory fibres to the trigeminal ganglion, where it establishes latency[3]. Interfering triggers such as psychological or physiological stress, UVB radiation, trauma, menstruation, sideropenia or febrile illness can provoke the reactivation of the virus[4,5]. Pain, tingling, or burning sensations in the affected area may occur This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. Several topical applications, such as phytotherapeuticals, natural remedies, photodynamic therapy, heat and laser application, as well as antiviral substances, can be provided[11,12,13,14,15,16]

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