Abstract
Objective To investigate the effect of hyperbaric oxygen intervention time on Glasgow Coma Score (GCS) and functional independent measure (FIM) scores in patients following traumatic brain injury, so as to provide clinical evidence for optimal intervention time in the comprehensive rehabilitation of those patients. Methods There were 130 patients with moderate or severe traumatic brain injury (TBI), who were divided according to different injury time into 4 groups: the control group (n=25), the HBO group 1 (TBI 30 d) (n=25). The patients in all the groups received drug therapy and rehabilitation treatment measures. On the basis of the above routine treatment, the patients in all the HBO groups were treated with HBO for a total of 40 sessions. Therapeutic efficacy was assessed by using GCS and FIM scores performed respectively at day one, day 30 and day 60. Results Statistical significance could be noticed in all the TBI groups in GCS and FIM scores performed at day 30 and day 60(P<0.01). For HBO group 1 and group 2, statistical differences could be seen in GCS scores detected at day 60(13.36±3.06, 13.66±1.42, 11.83±3.57), as compared with those of the control group(P<0.05). For HBO group 1 and group 2, statistical differences could also be seen in FIM scores detected respectively at day 30 and day 60, as compared with those of the control group(P<0.05). Variance in the scores of GCS and FIM was: group 1 was greater than group 2, group 2 was greater than group 3 and group 3 was greater than the control group. Conclusions Different HBO intervention time seemed to have some effect on the improvement of GCS and FIM scores in patients with traumatic brain injury. On the whole, treatment results indicated that the therapeutic effects for the HBO group 1 were superior to those for the HBO group 2, and the therapeutic effects for the HBO group 2 were superior to those for the HBO group 3. Key words: Hyperbaric oxygen; Rehabilitation; Intervention time; Functional independent measure; Glasgow Coma Score
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