Abstract

Objectives To study the feasibilty and safety of tacrolimus delaying the course of the grafted renal function failure.Methods The patients with abnormal grafted renal function after operation and chronic renal allograft nephropathy proved pathologically were collected.A cyclosporine-based regimen was converted to a tacrolimus-based regimen.The initial dose of tacrolimus was 0.15 mg·kg-1·d-1.Results All of the 10 patients had obvious decreases of blood cholesterol,blood creatinine level and high blood pressure after conversion to tacrolimus therapy.The number of antihypertensive drugs were significantly deceased.The GRF was significantly improved.Conclusions Conversion from cyclosporinehased regimen to tacrolimus-based regimen was an effective and safe alternative for delaying the course of renal function induced by chronic rejection of the allograft. Key words: Kidney transplantation; Kidney diseases; Kidney failure,chronic; Immunosuppressive agents

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