Abstract
Objective To explore the clinical effect of Sophora powder combined with Xianfang-Huoming decoction for ulcerative colitis. Methods A total of 80 UC patients with TCM syndrome of excessive noxious heat were randomly divided into 2 groups (40 patients each group). The Western medicine group(control group) were treated with Mesalazin Enteric-coated tablets, and the Traditional Chinese medicine(observation group) group were treated with Sophora powder combined with Xianfang-Huoming decoction. The tumor necrosis factor-α (TNF-α)and Interleukin-8 (IL-8) were detected. The Mayo index scores were conducted, and the curative effect and the recurrence rate were observed. Results After treatment, the level of TNF-α (66.11 ± 3.72 ng/L vs. 92.61 ± 4.32 ng/L,t=29.398, P<0.01), IL-8 (53.11 ± 2.72 ng/L vs. 69.31 ± 1.32 ng/L,t=33.888, P<0.01)in the observation group were significantly lower than those in the control group. The Mayo index score (2.07 ± 0.57 vs. 3.30 ± 0.93, t=7.132, P<0.01) in the observation group was significantly lower than that in the control group. The total effective rate (92.5% vs. 85.0%, χ2=1.127, P=0.288) in the observation group was not significantly different from that in the control group. The recurrence rate (5.4% vs. 26.5%, χ2=6.005, P=0.013) in the observation group was significantly lower than that in the control group. Conclusions The Sophora powder combined with Xianfang-Huoming decoction can treat the UC patients with TCM syndrome of excessive noxious hest, and the its recurrence rate is low. Key words: Colitis, Ulcerative; Huai Hua San; Xian Fang Huo Ming Yin; Mesalazine
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