Clinical study on repeat transurethral plasmakinetic resection of the bladder tumor in preventing the recurrence of the high risk non muscle invasive bladder cancer

Abstract

Objective To assess the clinical study of the repeat transurethral plasmakinetic resection of the bladder tumor (PKRBT) in preventing the recurrence rate of the high risk non muscle invasive bladder cancer (NMIBC).Methods 62 cases of high risk NMIBC treated by the first PKRBT were selected as the study objects from January 2010 to April 2012 and were randomly divided into experiment group and control group.Experiment group was treated by the repeat PKRBT for 4-6 weeks after the interval of the first resection,two groups were treated with adjuvant intravesical chemotherapy when finished resection.All of them were given a cystoscopy every three months and were followed up for 20 months,then we evaluated the tumor recurrence rates of the two groups.Results After 20 months of the following up in two groups,the recurrence rate of experiment group was 19.4％ and 41.9％ in control group,there was a significant reduction in experiment group compared with control group,the difference was statistically significant (P ＜ 0.05).Conclusion The tumor recurrence rate can been reduced when the patients with high risk NMIBC accept the repeat PKRBT and adjuvant intravesical chemotherapy after resection,and we can obtain more accurate pathological staging by it. Key words: Plasmakinetic resection of the bladder tumor(PKRBT); Bladder perfusion chemotherapy; High risk non muscle invasive bladder cancer