Clinical study on preventing and treating left ventricle remodeling after acute myocardial infarction with integrative Chinese and western medicine

Abstract

Objective: To explore the clinical efficacy of Xuefu Zhuyu, XFZY) oral liquid combined with western medicine (WM) in reversing left ventricle remodeling (LVR) after acute myocardial infarction (AMI) in patients and its therapeutic mechanism.Methods: Sixty patients conforming to criteria were divided into the treated group and WM control group with randomly stratified method. Thirty cases were assigned to each group, they were given XFZY + WM + general treatment and WM + general treatment respectively. Color Doppler ultrasonography was used to study the changes of LVR before and after treatment. Results: In both groups, before and after treatment theP value of such parameters as the changes of their left diastolic volume (LDV), left systolic volume (LSV), left ventricle ejection fraction (EF) was <0.05, suggesting that the difference of various parameters was significantly different; but when compared with the results of the 12th week after medications, the change of LDV, LSV, EF showed that the LDV, LSV of the treated group were lower than that of the control group, the EF of the treated group was higher than that of the control group, and theP value of various groups was all <0.05, suggesting that the different data of various groups showed significant difference.Conclusion: Conventional WM treatment and XFZY combined with WM could both, in treating AMI, effectively reverse the patients’ LVR; yet the use of integrative Chinese and western medicine on reversing patient’s LVR showed even better results than that of simple WM treatment.