Clinical study on preheating of substitution fluid to prevent hypothermia in patients with continuous renal replacement therapy

Abstract

Objective To explore the effect of preheating of substitution fluid on the incidence of hypothermia in patients with continuous renal replacement therapy (CRRT). Methods Use SPSS software to generate random Numbers, 98 cases were numbered in advance, and then randomly divided into control group and experimental group with 49 cases in each group. Control group based on the conventional way in the process of CRRT heating, experimental group preheating the substitution fluid to 37℃ in constant temperature box on the basis of conventional heating. The CRRT parameters of the two groups, the hourly body temperature of the patients and the arteriovenous temperature of the blood filtration catheter were recorded, and the laboratory indicators related to hemolysis before and after treatment were compared between the two groups. Results In the control group, the incidence of hypothermia at 6h, 12h, 18h, 24h, 48h and 72h was 20.41% (10/49), 32.65%(16/49), 40.82%(20/49), 48.98%(24/49), 55.10%(27/49), 59.18%(29/49), while the incidence of hypothermia in the experimental group at 6h, 12h, 18h, 24h, 48h and 72h was 6.12% (3/49), 14.29% (7/49), 20.41% (10/49), 28.57% (14/49), 34.69% (17/49), 38.78% (19/49), the incidence of hypothermia between the two groups was statistically significant (χ2=4.083-4.804, P 0.05). While the substitution fluid rate in 1 000-3 000 ml/h, the incidence of hypothermia in the control group was 50.00% (12/24), the incidence of hypothermia in the experimental group was 19.05% (4/21), the incidence of hypothermia in the experimental group was significantly lower than that in the control group (χ2=4.683, P 3000ml/h, the incidence of hypothermia in the control group was 93.33%(14/15), and that in the experimental group was 50.00%(11/22). The difference in the incidence of hypothermia between the two groups was statistically significant (P 0.05). Conclusions Preheating of substitution fluid can safely and effectively reduce the incidence of hypothermia in CRRT patients, and when the rate of substitution fluid was > 1 000ml/h, the effect of preventing hypothermia is more significant. Key words: Continuous renal replacement therapy; Hypothermia; Preheating of substitution fluid