Clinical study on inflammatory related factors in patients with non-valvular atrial fibrillation

Abstract

Objective To observe the correlation of inflammatory related factors with development of disease in patients with non-valvular atrial fibrillation (NVAF). Methods All the data were retrospectively analyzed. A total of 150 NVAF patients were selected as atrial fibrillation group, including 99 cases of non-paroxysmal atrial fibrillation (NPAF) and 51 cases of paroxysmal atrial fibrillation (PAF); 99 cases of NPAF included 58 cases of persistent atrial fibrillation and 41 cases of permanent atrial fibrillation. And 100 patients with sinus rhythm were selected as control group. All the patients underwent serum C-reactive protein (CRP) and high density lipoprotein cholesterol (HDL-C) examination. And 100 patients selected from atrial fibrillation group were treated with atorvastatin for 12 weeks. The changes of serum CRP and HDL-C of patients were observed before and after treatment. Results There was no statistically significant difference in the general information between atrial fibrillation group and control group (P>0.05); the level of serum CRP in atrial fibrillation group was higher than that in control group, but the level of HDL-C was lower than control group (P<0.05); the level of serum CRP in persistent atrial fibrillation group was higher than that in paroxysmal atrial fibrillation group, but the level of HDL-C was lower than paroxysmal atrial fibrillation group (P<0.05); after 100 patients in atrial fibrillation group were treated with atorvastatin for 12 weeks, the serum CRP levels decreased compared with those before treatment, the HDL-C levels increased compared with those before treatment (P<0.05). Conclusions The increased CRP and decreased HDL-C levels are key risk drives of causing atrial fibrillation, probably. CRP and HDL-C possibly can predict the occurrence and maintenance of atrial fibrillation. The application of statins in patients with atrial fibrillation can inhibit inflammatory response, reduce the occurrence and maintenance of atrial fibrillation, which has positive significance in improving patients’ prognosis. Key words: Atrial fibrillation; Inflammation; C-reactive protein; High density lipoprotein cholesterol