Clinical study on corneal endothelial cell damage and repair of type 2 diabetes mellitus after phacoemulsification

Abstract

Objective To study the influence of duration of type 2 diabetes and severity of diabetic retinopathy to corneal endothelial cells morphology after phacoemulsification.Method 50 cases (58 eyes)with type 2 diabetes in group B and 30 cases(44 eyes) without diabetes in group A underwent phaco + IOL implantation.Further,according to the duration of diabetes,the patient of group B were devided into group B1(less than 10 years) and group B2(more than 10 years),according to the the severity of diabetic retonopathy,the patient of group B were devided into group B3 (＜ grade 3) and group B4 (≥ grade 3).The change of endothelial cells was observed.Result The difference of morphology of coneal endothelial between group A and group B was statistical significant before and after surgery.The corneal endothelial cell density(CD),decline degree of percentage of hexagonal ceils,rising degree of coefficient of variation (CV) were higher in group A than in group B (P ＜ 0.05).A significant increase in CV was seen in the group B2 than did in the group B1 (P ＜ 0.05) ;Also the increase in CV of group B4 was statistically higher compared with group B3 (P ＜ 0.05).Conclusion Duration of diabetes and severity of retinopathy are important factors affecting the corneal endothelial morphology and function. Key words: Corneal endothelial cell ; Cataract ; Phacoemulsification; Type 2 diabetes