Clinical study on chronic hepatitis B virus infected patients superinfected with hepatitis E virus

Abstract

Objective To investigate the clinical features of chronic hepatitis B virus (HBV) infected patients superinfected with hepatitis E virus (HEV),and the risk factors of acute sporadic HEV case.Explore reasonable treatment to reduce the incidence of severe viral hepatitis and mortality in the HBV/HEV superinfection.Methods The clinical characteristics of the patients with HBV and HEV superinfection were compared with those simple HEV infection.Results A total of 115 hepatitis E cases were all acute attack with an average of (42 ± 15) years old and the ratio of male to female was 2.83∶ 1.The 44 cases of them were HBV/HEV superinfection,the other 71 cases were the simple hepatitis E.In the HBV/HEV superinfection group the sever jaundice (TB ＞ 200 μmol/L),the severe abnormal coagulation function( PTA ＜40％ ),the hypoalbuminemia was obviously more than that in the simple hepatitis E group( P ＜ 0.05).The incidence of hepatic encephalopathy was 15.90％,the severe hepatitis rate was 38.64％,obviously higher than that in the simple hepatitis E group (P ＜ 0.05 ).ALSS has good effects in the treatment of the patients with severe viral hepatitis.Conclusions Seafood were the risk factors in the infection of HEV.Superinfection of HBV and HEV can cause chronic and more severe hepatitis,with high mortality.Combined hepatotherapy with ALSS has good effects,the general survival rate is higher,especially in early stage. Key words: Hepatitis B virus; Hepatitis E virus; Superinfection; Severe viral hepatitis