Clinical study on changes of inflammatory factor and vascular endothelial growth factor in patients with type II diabetes mellitus complicated with retinopathy

Abstract

Objective To investigate the changes of inflammatory factors and vascular endothelial growth factor (VEGF) in patients with type Ⅱ diabetes complicated with proliferative diabetic retinopathy (PDR). Methods The clinical data of 216 patients with type Ⅱ diabetes treated in Jiaozhou People’s Hospital from October 2016 to September 2018 were selected. The patients were divided into PDR group (n=102) and non-PDR group (n=114) according to whether the patient had PDR. The peripheral blood related indicators and biochemical indicators of the two groups were detected and compared. Peripheral blood related indicators included: C-reactive protein (CRP), vascular endothelial growth factor(VEGF), interleukin-10 (IL-10) and interleukin-6 (IL-6). Biochemical indicators including total cholesterol (TC), triglyceride (TG) and hemoglobin a1c (HbA1c) were determined 3 times, and value of each indicator was averaged. Results Compared with the non-PDR group, the peripheral blood IL-6 and VEGF levels were significantly higher in the PDR group (t=5.777, 19.057, P all<0.01). Compared with patients in the non-PDR group, the HbA1c level was significantly increased in the PDR group (t=16.570, P<0.01). Pearson correlation test showed that IL-6 and HbA1c levels were positively correlated with VEGF levels (r=0.714, 0.676, P all<0.01). Conclusions The VEGF of peripheral blood in patients with type Ⅱ diabetes mellitus complicated with retinopathy is significantly increased, which may be associated with inflammatory mediators and huperycemia leading to eye lesions in patients. Key words: Type Ⅱ diabetes mellitus; Retinopathy; Inflammatory factor; Vascular endothelial growth factor